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Modelling and Planning Optimization of a Complex Flu Vaccine Facility

Paper ID Volume ID Publish Year Pages File Format Full-Text
19301 43058 2006 12 PDF Available
Title
Modelling and Planning Optimization of a Complex Flu Vaccine Facility
Abstract

This work describes medium-term planning and scheduling in a flu vaccine manufacturing facility. As flu vaccine manufacturers expand into global markets and exploit global multi-sourced supply arrangements, optimization of complex flu vaccine facilities is required to lower costs, increase return on assets, and increase market share. The manufacturing process consists of four main stages: egg processing, whole virus purification, split virus purification and packaging. Each requires many different process operations and resources. Overall, the process comprises a large number of process stages with many intermediates, and this level of complexity presents a significant challenge to model. A model is developed to identify any changes in the current configuration of the process which enables the manufacturing times to be shortened and the responsiveness improved by identifying bottlenecks. Given the available equipment, product delivery dates and equipment requirements for the vaccine products, the problem is to schedule batches in order to meet the delivery dates. The problem is solved using a hybrid model with a computational heuristic at the front-end and optimization at the back-end. It determines the key decisions related to the system, including the sequence of activities, batch sizes, and timing of process operations. The objectives are (1) to understand how different parameters and decisions affect performance; (2) to identify the most important factors in the supply chain; (3) to evaluate a new operational strategy; and (4) to reduce time-to-market without large capital investment. The results show how the flu vaccine manufacturing plant can manage to meet existing demands and extra demands. Additionally, a debottlenecking study is undertaken.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Food and Bioproducts Processing - Volume 84, Issue 2, June 2006, Pages 123-134
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us