fulltext.study @t Gmail

The Manufacture and Characterization of Casein Films as Novel Tablet Coatings

Paper ID Volume ID Publish Year Pages File Format Full-Text
19500 43070 2007 7 PDF Available
Title
The Manufacture and Characterization of Casein Films as Novel Tablet Coatings
Abstract

The use of casein as a novel film-forming agent, capable of functioning as a pharmaceutical tablet coat, was assessed. Diltiazem HCl core tablets were coated with casein using a pan coater and the efficacy of four different plasticizing agents (glycerol, triethyl citrate, dibutyl sebacate and oleic acid) in producing a continuous tablet-coat were evaluated. Interestingly, only those films formed using oleic acid as a plasticizing agent were capable of producing a continuous, acceptable coat. Consequently, the drug dissolution properties of casein/oleic acid film-coated tablets in pH 1.2 and pH 6.8 media were further investigated. Post-coating thermal treatment (60, 80 and 100°C) was shown to have a significant effect on the properties of the casein-oleic acid films. Diltiazem HCl drug release at pH 1.2 was found to decrease with increasing post-coating heat treatment temperature. Additionally, only coated tablets that were subjected to post-coating heat treatment at 100°C showed sustained drug release properties at pH 6.8, which may be attributed to casein cross-linking.

Keywords
casein; oleic acid; coating; cross-linking; sustained release
First Page Preview
The Manufacture and Characterization of Casein Films as Novel Tablet Coatings
Publisher
Database: Elsevier - ScienceDirect
Journal: Food and Bioproducts Processing - Volume 85, Issue 3, September 2007, Pages 284–290
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering