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Hydrogel nanocomposites as remote-controlled biomaterials

Paper ID Volume ID Publish Year Pages File Format Full-Text
1965 96 2008 6 PDF Available
Title
Hydrogel nanocomposites as remote-controlled biomaterials
Abstract

Nanocomposite hydrogels are a new class of intelligent materials which have recently attracted interest as biomaterials. In this study, magnetic nanocomposites of temperature-sensitive hydrogels have been developed and demonstrated to be responsive to alternating magnetic fields. Nanocomposites were synthesized by incorporation of superparamagnetic Fe3O4 particles in negative temperature-sensitive poly(N-isopropylacrylamide) hydrogels. The systems were characterized for temperature-responsive swelling, remote heating on application of an alternating magnetic field and remote-controlled drug delivery applications. The rise in temperature in external alternating magnetic field depends on the Fe3O4 particle loading of the system. Preliminary studies on remote-controlled drug release showed reduced release in the presence of an alternating magnetic field.

Keywords
Hydrogel; Nanocomposite; Remote control; Drug delivery; Magnetic
First Page Preview
Hydrogel nanocomposites as remote-controlled biomaterials
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 1, January 2008, Pages 11–16
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering