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Superporous hydrogels for cartilage repair: Evaluation of the morphological and mechanical properties

Paper ID Volume ID Publish Year Pages File Format Full-Text
1966 96 2008 9 PDF Available
Title
Superporous hydrogels for cartilage repair: Evaluation of the morphological and mechanical properties
Abstract

Despite extensive research in the design of biomaterials for articular cartilage repair, there remains a need for the development of materials with the mechanical compliance to function synergistically with healthy cartilage, but porous enough to allow for tissue integration. In this study, superporous hydrogels of poly(vinyl alcohol) and poly(vinyl pyrrolidone) were prepared using a novel technique consisting of a double emulsion process. The hydrogel emulsions were physically cross-linked by freeze–thaw cycling. The hydrogels had a high degree of porosity, determined using environmental scanning electron microscopy, a technique superior to any method that involves dehydrating the samples. Increasing the volume of organic solvent increased porosity, due to cross-linking of the hydrogel solution around the droplets in the emulsion, leaving pores where the organic solvent was present. Poly(lactic-co-glyclic acid) microparticles formed and were embedded in the matrix. The mechanical properties, measured in confined creep and in unconfined, uniaxial compression, were similar to native articular cartilage. The permeability of the samples was unaffected by changing solvent content, despite changes in porosity. These materials are good candidates for tissue engineering of cartilage because they can mimic mature cartilage mechanically while providing a porous matrix through which cells can migrate and proliferate.

Keywords
Hydrogels; Porosity; Cartilage; Creep
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Superporous hydrogels for cartilage repair: Evaluation of the morphological and mechanical properties
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 1, January 2008, Pages 17–25
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us