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Suture-reinforced electrospun polydioxanone–elastin small-diameter tubes for use in vascular tissue engineering: A feasibility study

Paper ID Volume ID Publish Year Pages File Format Full-Text
1970 96 2008 9 PDF Available
Title
Suture-reinforced electrospun polydioxanone–elastin small-diameter tubes for use in vascular tissue engineering: A feasibility study
Abstract

This study characterizes the cross-linking of electrospun elastin and the mechanical properties of suture-reinforced 1.5 mm internal diameter electrospun tubes composed of blended polydioxanone (PDO) and soluble elastin. Several tube configurations were tested to assess the effects of reinforcement on tube mechanical properties. Between the electrospun layers of each double-layered prosthetic, zero, one or two 6-0 sutures were wound, maintaining 1 mm spacing with a pitch of 9°. Single-layered tubes without suture were also examined. Samples were cross-linked and tested for compliance and burst strength. Compliance decreased significantly (p < 0.05) and burst strength significantly increased (p < 0.01) with reinforcement. Uncross-linked tubes were also tested to determine the effects of cross-linking. Results demonstrated that cross-linking significantly decreases burst strength (p < 0.01), while decreases in compliance for cross-linked tubes were not significant. Cross-linked suture-reinforced PDO–elastin tubes had burst pressures more than 10 times greater than normal systolic pressures and exhibited a range of compliance values, including those matching native artery. These tubes display many characteristics of the “ideal” small-diameter graft, having mechanical properties that can be tailored to match those desired in vascular replacement applications.

Keywords
Electrospinning; Vascular grafts; Polydioxanone; Elastin; Cross-linking
First Page Preview
Suture-reinforced electrospun polydioxanone–elastin small-diameter tubes for use in vascular tissue engineering: A feasibility study
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 1, January 2008, Pages 58–66
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering