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Fatty acid metabolism: Implications for diet, genetic variation, and disease

Paper ID Volume ID Publish Year Pages File Format Full-Text
19731 43123 2013 12 PDF Available
Title
Fatty acid metabolism: Implications for diet, genetic variation, and disease
Abstract

Cultures across the globe, especially Western societies, are burdened by chronic diseases such as obesity, metabolic syndrome, cardiovascular disease, and cancer. Several factors, including diet, genetics, and sedentary lifestyle, are suspected culprits to the development and progression of these health maladies. Fatty acids are primary constituents of cellular physiology. Humans can acquire fatty acids by de novo synthesis from carbohydrate or protein sources or by dietary consumption. Importantly, regulation of their metabolism is critical to sustain balanced homeostasis, and perturbations of such can lead to the development of disease. Here, we review de novo and dietary fatty acid metabolism and highlight recent advances in our understanding of the relationship between dietary influences and genetic variation in fatty acid metabolism and their role in chronic diseases.

Keywords
SNP, single nucleotide polymorphism; SAFA, saturated fatty acid; MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid; ACLY, ATP citrate lyase; ACACA, acetyl-CoA carboxylase 1; ACACB, acetyl-CoA carboxylase 2; FASN, fatty acid synthase; ELOV
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Fatty acid metabolism: Implications for diet, genetic variation, and disease
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Publisher
Database: Elsevier - ScienceDirect
Journal: Food Bioscience - Volume 4, December 2013, Pages 1–12
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us