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Attenuation of streptozotocin-induced alterations in acetylcholinesterase and antioxidant system by S-allylcysteine in rats

Paper ID Volume ID Publish Year Pages File Format Full-Text
19734 43123 2013 7 PDF Available
Title
Attenuation of streptozotocin-induced alterations in acetylcholinesterase and antioxidant system by S-allylcysteine in rats
Abstract

•S-allylcysteine is a sulfur containing amino acid derived from garlic.•It may constitute an alternative to insulin in diabetic model.•This compound may be used as an alternative against synthetic compound.

The present study was designed to investigate the effect of the administration of S-allylcysteine (SAC) (150 mg/kg body weight for 45 days) on acetylcholinesterase (AChE) activity and antioxidant levels in the brain tissues of streptozotocin-induced diabetic rats. The levels of glucose, TBARS, hydroperoxide and acetylcholinesterase were increased significantly whereas the levels of plasma insulin, reduced glutathione, superoxide dismutase and catalase were decreased in experimental diabetic rats. Administration of SAC to diabetic rats reverted all these parameters. The effect of SAC was compared with glyclazide, a well-known antioxidant and antihyperglycemic drug. In conclusion, the present findings showed that treatment with SAC prevents the increase in AChE activity, lipid peroxidation, and consequently improves the antioxidant system in diabetic rats, indicating that this compound can be considered as possible therapeutics to be investigated in brain disorders associated with the diabetes.

Keywords
SAC, S-allylcysteine; STZ, streptozotocin; kg, kilogramAcetylcholinesterase; Antioxidants; Diabetes mellitus; Streptozotocin; S-allyl cysteine; Rats
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Attenuation of streptozotocin-induced alterations in acetylcholinesterase and antioxidant system by S-allylcysteine in rats
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Publisher
Database: Elsevier - ScienceDirect
Journal: Food Bioscience - Volume 4, December 2013, Pages 31–37
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us