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Essential oils of E. uniflora leaves protect liver injury induced by acetaminophen

Paper ID Volume ID Publish Year Pages File Format Full-Text
19737 43123 2013 8 PDF Available
Title
Essential oils of E. uniflora leaves protect liver injury induced by acetaminophen
Abstract

The goal of this work was to evaluate the hepatoprotector activity of Eugenia uniflora leaves essential oil in mice by the determination of the biochemical parameters: thiobarbituric acid reactive species, δ-aminulevunilate dehydratase, glutathione-S-transferase and catalase activities, non-protein thiol, and plasmatic levels of aspartate aminotransferase and alanine aminotransferase. The E. uniflora leaves essential oil (200 mg/kg) restored all of the biochemical parameters modified by the injury caused by the acetaminophen (300 mg/kg), like non-protein thiol content, δ-aminulevunilate dehydratase and glutathione-S-transferase activities on mice's liver and also decreased the levels of thiobarbituric acid reactive species on kidneys. Moreover, the increase on plasma activities aspartate aminotransferase and alanine aminotransferase was also restored by the essential oil. The exposure to acetaminophen also increased lipid peroxidation in liver and kidney. This work shows for the first time the effect of E. uniflora leaves essential oil on attenuating the injury caused by acetaminophen on mice.

Keywords
Essential oil; Acetaminophen; Oxidative stress
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Essential oils of E. uniflora leaves protect liver injury induced by acetaminophen
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Publisher
Database: Elsevier - ScienceDirect
Journal: Food Bioscience - Volume 4, December 2013, Pages 50–57
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us