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Anthocyanin extract of Lannea microcarpa fruits stall oxidative rout associated with aflatoxin B1 hepatocarcinogenesis

Paper ID Volume ID Publish Year Pages File Format Full-Text
19738 43123 2013 10 PDF Available
Title
Anthocyanin extract of Lannea microcarpa fruits stall oxidative rout associated with aflatoxin B1 hepatocarcinogenesis
Abstract

The capability of anthocyanins extract of Lannea microcarpa fruits to scavenge reactive oxygen species and stall aflatoxin B1-mediated oxidative rout on cellular proteins, lipids and DNA was investigated. Reactive oxygen species (ROS) scavenging potentials of the anthocyanins extract of Lannea microcarpa fruits (0.2–1.0 mg/mL) was investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, superoxide ion, hydrogen peroxide, hydroxyl radical and ferric ion reducing system. Anthocyanins extract at 1.0 mg/mL scavenged DPPH, superoxide ion, hydrogen peroxide, and hydroxyl radical by 91%, 88%, 90% and 83%, respectively, it also reduced ferric ion significantly. The specific activities of reactive oxygen species detoxifying enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase) were significantly (P<0.05) induced by Lannea microcarpa fruits anthocyanins. These inductions significantly (P<0.05) attenuated the aflatoxin B1-mediated decrease in reactive oxygen species detoxifying enzymes and compared favorably with Vitamin C. Aflatoxin B1-mediated elevation in the concentrations of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl and fragmented DNA were significantly (P<0.05) lowered by Lannea microcarpa fruits anthocyanins. Overall, the results of this study show that Lannea microcarpa fruits anthocyanins possesses antioxidant properties and halted aflatoxin B1-mediated oxidative rout on cellular proteins, lipids and DNA.

Keywords
Lannea microcarpa fruits; DNA fragmentation; Lipid peroxidation; Aflatoxin B1; Oxidative stress biomarkers; Reactive oxygen species
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Anthocyanin extract of Lannea microcarpa fruits stall oxidative rout associated with aflatoxin B1 hepatocarcinogenesis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Food Bioscience - Volume 4, December 2013, Pages 58–67
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us