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Hepatoprotective and proteomic mechanism of Sphaeranthus indicus in paracetamol induced hepatotoxicity in wistar rats

Paper ID Volume ID Publish Year Pages File Format Full-Text
19783 43128 2013 9 PDF Available
Title
Hepatoprotective and proteomic mechanism of Sphaeranthus indicus in paracetamol induced hepatotoxicity in wistar rats
Abstract

•Hepatoprotective and proteomic analysis on Sphaeranthus indicus extract using rats.•Sustain the antioxidant status.•Sphaeranthus indicus could be used as food supplement.

The present study was carried out to explore the hepatoprotective and proteomic mechanisms of Sphaeranthus indicus in paracetamol induced hepatotoxicity in rats using 2D gel and MALDI-TOF-MS. Oral administration of ethanolic and aqueous extract of S. indicus to the paracetamol induced rats' showed increase of both enzymatic and non-enzymatic antioxidant status and decreased lipid peroxide level. For proteomic approach, identified the four differential spots were expressed in paracetamol induced and S. indicus treated rats through 2D gel. The expressions of these protein spots were further confirmed by MALDI-TOF-MS i.e. Heat shock protein, Liver transferrin, Glutathione-S-Transferase and Carnitine palmitoyl transferase. These identified proteins involved in many cellular activities like maintain cellular integrity, iron transport, free radical scavenging activity and β oxidation of fatty acids. These results were given more information about antioxidant activity of extracts. Therefore, the plant extracts could be used safely as food supplement for antioxidant activities enhancements.

Keywords
Sphaeranthus indicus; Hepatoprotective; Antioxidant; 2D gel; MALDI-TOF-MS
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Hepatoprotective and proteomic mechanism of Sphaeranthus indicus in paracetamol induced hepatotoxicity in wistar rats
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Publisher
Database: Elsevier - ScienceDirect
Journal: Food Bioscience - Volume 1, March 2013, Pages 57–65
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us