fulltext.study @t Gmail

Morphological stability of microencapsulated vitamin formulations by AFM imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
19888 43140 2016 12 PDF Available
Title
Morphological stability of microencapsulated vitamin formulations by AFM imaging
Abstract

•Lipophilic vitamins were formulated in microencapsulated product forms.•Internal particle morphology of Vitamin A formulations was visualized by AFM.•Changes in this morphology by increased temperature or humidity were evaluated.•The morphological stability was affected by matrix composition.•Morphological stability was predicted with accelerated AFM stress tests.

The morphological stability of microencapsulated lipophilic vitamin formulations directly influences the long-term storage stability and performance in final applications. The internal particle morphology of three commercial dry Vitamin A acetate formulations differing in their matrix composition (hydrocolloid/polysaccharide and plasticizer) was systematically characterized by atomic force microscopy (AFM). The evolution of the particle internal morphology after per-se storage at 25 and 40 °C for ten months was investigated. Furthermore, an accelerated stress test by in-situ heating and AFM imaging was developed. Surface roughness parameters from the AFM images were used to semi-quantitatively estimate the evolution of the particle internal microstructure, and thus the aging and destabilization of the lipophilic vitamin formulations. The influence of humidity level on the thermal morphological restructuring of one of the commercial samples was also investigated. This study has shown that such AFM investigations of microparticles are a novel analytical tool to rapidly estimate the physical stability of the lipophilic vitamin dried emulsions.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Atomic force microscopy; Microencapsulation; Vitamin; Formulation; Emulsion; Surface roughness parameters
First Page Preview
Morphological stability of microencapsulated vitamin formulations by AFM imaging
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Food Structure - Volume 9, July 2016, Pages 1–12
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us