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Optimization of RNA-based c-di-GMP fluorescent sensors through tuning their structural modules

Paper ID Volume ID Publish Year Pages File Format Full-Text
19998 43152 2016 5 PDF Available
Title
Optimization of RNA-based c-di-GMP fluorescent sensors through tuning their structural modules
Abstract

Cyclic diguanylate (c-di-GMP) is a second messenger of bacteria and its detection is an important issue in basic and applied microbiology. As c-di-GMP riboswitch ligand-binding domains (aptamer domains) capture c-di-GMP with high affinity and selectivity, they are promising platforms for the development of RNA-based c-di-GMP sensors. We analyzed two previously reported c-di-GMP sensor RNAs derived from the Vc2 riboswitch. We also designed and tested their variants, some of which showed improved properties as RNA-based c-di-GMP sensors.

Keywords
c-Di-GMP; Fluorescent sensor; RNA-based sensor; Riboswitch; Spinach RNA
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Optimization of RNA-based c-di-GMP fluorescent sensors through tuning their structural modules
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 122, Issue 2, August 2016, Pages 183–187
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us