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Insights into copper effect on Proteus hauseri through proteomic and metabolic analyses

Paper ID Volume ID Publish Year Pages File Format Full-Text
20017 43153 2016 8 PDF Available
Title
Insights into copper effect on Proteus hauseri through proteomic and metabolic analyses
Abstract

This is the first-attempt to use liquid chromatography coupled with tandem mass (LC-MS-MS) in deciphering the effects of copper ion on Proteus hauseri. Total 941 proteins in copper-addition (+Cu) group and 898 proteins in non-copper-addition (−Cu) group were found, which containing 221 and 178 differential proteins in +Cu and −Cu group, respectively. Differential proteins in both groups were defined into 14 groups by their functional classification which transport/membrane function proteins were the major different part between the two groups, which took 19.5% and 7.7%, respectively. The result of BioCyc and KEGG analyses on metabolic pathway indicated that copper could interrupted the pathway of chemotaxis CheY and inhibited the swarming of P. hauseri, which provided a potential in controlling the pathogenicity of this strain.

Keywords
Proteus hauseri; Copper; Proteomics; Motility; Metabolic
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Insights into copper effect on Proteus hauseri through proteomic and metabolic analyses
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 121, Issue 2, February 2016, Pages 178–185
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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