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Plasma-induced nanopillars on bare metal coronary stent surface for enhanced endothelialization

Paper ID Volume ID Publish Year Pages File Format Full-Text
2003 97 2010 7 PDF Available
Title
Plasma-induced nanopillars on bare metal coronary stent surface for enhanced endothelialization
Abstract

An increased risk of late stent thrombosis associated with polymer carriers on the surface of drug-eluting stents remains one of the challenges in cardiovascular stent technology, which has instigated a renewed interest in the polymer-less, bare metal stent approach. As thrombus formation is most likely augmented by the lack of endothelial cell coverage at the exposed stented site, an improved stent surface that enhances cell coverage is essential for viable polymer-less all metal stents. We demonstrate superior endothelial cell growth, more continuous monolayer formation and overall improved endothelialization with nanopillar arrays created via radio frequency plasma surface texturing on our all metallic stent surface of MP35N stent alloy. It is shown that the nanotextured surface significantly up-regulates primary bovine aortic endothelial cell (BAEC) functionality when compared with unprocessed, smooth MP35N surfaces without a nanopillar topography. The desirable presence of transmembrane tight junctions and highly organized monolayer formation was induced by the presence of the nanopillar surface texture. The nanopillar structure also produced a reduced level of oxidative stress in the BAECs. These findings may contribute to new nanotechnology-based surface design concepts for bare metal stents producing advanced cardiovascular implants which mitigate late stent thrombosis.

Keywords
Nanopillar; Surface texture; Endothelial cell; Cardiovascular; Stent
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Plasma-induced nanopillars on bare metal coronary stent surface for enhanced endothelialization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 12, December 2010, Pages 4589–4595
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us