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Improved conversion of cinnamaldehyde derivatives to diol compounds via a pyruvate decarboxylase-dependent mechanism in budding yeast

Paper ID Volume ID Publish Year Pages File Format Full-Text
20031 43154 2016 3 PDF Available
Title
Improved conversion of cinnamaldehyde derivatives to diol compounds via a pyruvate decarboxylase-dependent mechanism in budding yeast
Abstract

Cinnamaldehyde is stereospecifically converted to (2S,3R) 5-phenylpent-4-ene-2,3-diol, an important starting material for the synthesis of biologically active compounds, by the budding yeast Saccharomyces cerevisiae. Immobilization of the yeast in calcium alginate capsules suppressed the formation of by-products and increased accumulation of the diol compounds. The mechanism of cinnamaldehyde conversion was investigated by using recombinant strains of Escherichia coli and S. cerevisiae carrying the pyruvate decarboxylase gene PDC1. As a result, condensation of the substrate with acetaldehyde was enhanced by PDC and flow to the diol product was altered.

Keywords
Bioconversion; Cinnamaldehyde; Diol; Immobilized yeast; Saccharomyces cerevisiae; Pyruvate decarboxylase
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Improved conversion of cinnamaldehyde derivatives to diol compounds via a pyruvate decarboxylase-dependent mechanism in budding yeast
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 121, Issue 3, March 2016, Pages 265–267
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us