fulltext.study @t Gmail

DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification

Paper ID Volume ID Publish Year Pages File Format Full-Text
20160 43160 2015 4 PDF Available
Title
DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification
Abstract

We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active.

Keywords
DNA damage; p53 promoter; Tetracycline transactivator; Inducible gene expression
First Page Preview
DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 120, Issue 4, October 2015, Pages 463–466
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering