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Challenges to production of antibodies in bacteria and yeast

Paper ID Volume ID Publish Year Pages File Format Full-Text
20164 43161 2015 8 PDF Available
Title
Challenges to production of antibodies in bacteria and yeast
Abstract

Currently, antibodies play major role in treating a wide variety of human diseases (e.g., cancer, viral infection, inflammation). Those pharmaceutic antibodies have become major therapeutic reagents in the pharmaceutical drug market. In addition to full-length antibodies, the market of antibody fragments, which offer potential advantages in clinical use as well as diagnostics, is gradually growing. As the demand for antibody therapeutics increase, the development of host systems for enhanced, and less expensive, production has also become more important. All therapeutic antibodies approved to date are predominantly produced in mammalian hosts, but due to drawbacks such as high production cost and long-term cultivation, the alternative use of bacteria and yeasts has been seriously considered. Recently, there have been reports of substantial progress in genetic engineering and systems biotechnology, results in development of potential hosts that overcame the critical limitations in bacterial and yeast cells, and much enhanced productivity of functional antibodies. In this review, we highlight recent, significant progress made in the engineering of bacterial and yeast cells for enhanced production of functional antibodies.

Keywords
Antibody; Antibody fragments; Escherichia coli; Yeast
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 120, Issue 5, November 2015, Pages 483–490
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us