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Three-dimensional scaffold of electrosprayed fibers with large pore size for tissue regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
2019 97 2010 9 PDF Available
Title
Three-dimensional scaffold of electrosprayed fibers with large pore size for tissue regeneration
Abstract

The regeneration of tissues using biodegradable porous scaffolds has been intensely investigated. Since electrospinning can produce scaffolds mimicking nanofibrous architecture found in the body, it has recently gained widespread attention. However, a major problem is the lack of pore size necessary for infiltration of cells into the layers below the surface, restricting cell colonization to the surfaces only. This study describes a novel twist to the traditional electrospinning technology: specifically, collector plates are designed which allow the formation of very thin layers with pore sizes suitable for cell infiltration. The thin samples could be handled without mechanically damaging the structure and could be transferred into cell culture. These thin layers were stacked layer-by-layer to develop thick structures. Thirty day cultures of fibroblasts show attachment and spreading of cells in every layer. This concept is useful in regenerating thick tissues with uniformly distributed cells and others in in vitro cell culture.

Keywords
Electrospraying; PCL; Gelatin; Tissue regeneration; Porous structure
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Three-dimensional scaffold of electrosprayed fibers with large pore size for tissue regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 12, December 2010, Pages 4734–4742
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us