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Rapid evaluation of N-glycosylation status of antibodies with chemiluminescent lectin-binding assay

Paper ID Volume ID Publish Year Pages File Format Full-Text
20276 43166 2015 4 PDF Available
Title
Rapid evaluation of N-glycosylation status of antibodies with chemiluminescent lectin-binding assay
Abstract

•Rapid and high-throughput detection for antibody glycosylation.•The detection is based on chemiluminescent-bead-based lectin binding.•This method is applicable to evaluation of glycosylation dynamics in cell culture.

We constructed an assay system for the rapid detection of the glycosylation status of antibodies with a chemiluminescence-based lectin-binding assay, and investigated the glycosylation dynamics during the culture of recombinant Chinese hamster ovary cells. This rapid detection system is applicable to the high-throughput evaluation of therapeutic glycoproteins.

Keywords
Glycosylation; Antibody; Chinese hamster ovary cells; Lectin; Chemiluminescent assay
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Rapid evaluation of N-glycosylation status of antibodies with chemiluminescent lectin-binding assay
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 120, Issue 1, July 2015, Pages 107–110
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us