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Surface modification of three-dimensional poly(d,l-lactic acid) scaffolds with baicalin: A histological study

Paper ID Volume ID Publish Year Pages File Format Full-Text
2039 98 2007 9 PDF Available
Title
Surface modification of three-dimensional poly(d,l-lactic acid) scaffolds with baicalin: A histological study
Abstract

To improve the biocompatibility of three dimensional (3D) poly(d,l-lactic acid) (PDLLA), surface modification with baicalin was performed via a physical entrapment method in this study. The tissue reactions and bone conductivities of such modified PDLLA scaffolds were histologically assessed by using a rabbit radialis defect model in vivo. The native PDLLA scaffolds were prepared via a thermally induced phase separation technique and were characterized by scanning electron microscopy and fluorescence microscopy. The tissue reactions and bone conductivities of both baicalin-modified PDLLA scaffolds and native PDLLA scaffolds were comparably evaluated with histological assay and histomorphometry at different implantation intervals (2, 4, 8 and 12 weeks). Osteocalcin assay, a method to evaluate the bone formation potential, has shown that the osteocalcin production in the baicalin-modified 3D PDLLA scaffold group was significantly higher (p < 0.01 or <0.05) than that in the control. Histological observation and histomorphometry results reflected a higher bone formation potential and better biocompatibility of baicalin-modified PDLLA scaffold when compared with those of the native PDLLA scaffolds.

Keywords
Poly(d,l-lactic acid); Baicalin; Entrapment; Bone formation; Osteocalcin
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Surface modification of three-dimensional poly(d,l-lactic acid) scaffolds with baicalin: A histological study
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 4, July 2007, Pages 597–605
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us