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Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces cerevisiae

Paper ID Volume ID Publish Year Pages File Format Full-Text
20424 43174 2014 6 PDF Available
Title
Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces cerevisiae
Abstract

Vanillin and furfural are derived from lignocellulosic biomass and inhibit yeast growth and fermentation as biomass conversion inhibitors. Furfural has been shown to induce oxidative stress in Saccharomyces cerevisiae. Since there has been no report on the relationship between vanillin and oxidative stress, we investigated whether vanillin caused oxidative stress in yeast cells. We showed that vanillin caused the nuclear accumulation of Yap1, an oxidative stress responsive transcription factor, and subsequent transcriptional activation of Yap1-target genes. The growth of the null mutant of the YAP1 gene (yap1Δ) was delayed in the presence of vanillin, which indicated that Yap1 plays a role in the acquisition of tolerance to vanillin. We also demonstrated that vanillin facilitated the fragmentation of mitochondria. These findings suggest that the toxicity of vanillin involves damage induced by oxidative stress.

Keywords
Vanillin; Furfural; Yap1; Lignocellulosic biomass; Mitochondrial fragmentation; Saccharomyces cerevisiae
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Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces cerevisiae
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 117, Issue 1, January 2014, Pages 33–38
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us