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Binding affinity of ssDNA is improved by attachment of dsDNA regions

Paper ID Volume ID Publish Year Pages File Format Full-Text
20441 43175 2014 3 PDF Available
Title
Binding affinity of ssDNA is improved by attachment of dsDNA regions
Abstract

LidNA, a microRNA inhibitor consisting of a microRNA binding ssDNA region sandwiched between dsDNA regions had higher affinity to target oligonucleotides than that without dsDNA region. This enhancement in affinity was found to be owing to the suppressed mobility of ssDNA region by the presence of dsDNA regions.

Keywords
MicroRNA inhibitor; LidNA; ssDNA binding affinity; Surface plasmon resonance; Fluorescence polarization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 118, Issue 3, September 2014, Pages 239–241
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us