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Preparation of a collagen/polymer hybrid gel designed for tissue membranes. Part I: Controlling the polymer–collagen cross-linking process using an ethanol/water co-solvent

Paper ID Volume ID Publish Year Pages File Format Full-Text
2052 99 2010 6 PDF Available
Title
Preparation of a collagen/polymer hybrid gel designed for tissue membranes. Part I: Controlling the polymer–collagen cross-linking process using an ethanol/water co-solvent
Abstract

The drawback with collagen/2-methacryloyloxyethyl phosphorylcholine (MPC) polymer hybrid gels (collagen/phospholipid polymer hybrid gels) prepared in alkaline morpholinoethane sulfonic acid (MES) aqueous solution is that the cross-linking rate between the polymer and the collagen is low. To solve this problem, ethanol has been adopted as the reaction solvent, to prevent 1-ethyl-3-(3-dimethylaminopropyl)-1-carbodiimide hydrochloride (EDC) hydrolysis. Alterations in the ethanol mole concentration changed the cross-linking rate between the MPC polymer and the collagen gel. Prevention of EDC hydrolysis is clearly observed; protonation of carboxyl groups implies that the ratio of ethanol to water should be controlled. The polymer shows signs of penetration into the collagen gel layer, thus forming a totally homogeneous phase gel. This affects the mechanical strength of the collagen gel, making the gel much stiffer and brittle with an increase in the swelling ratio, as compared with that prepared in MES buffer. However, it is possible to obtain a collagen/phospholipid polymer hybrid gel with a high polymer portion and the cross-linking rate can be successfully controlled.

Keywords
Collagen; Cross-link; Phospholipid polymer; Hydrogel
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Preparation of a collagen/polymer hybrid gel designed for tissue membranes. Part I: Controlling the polymer–collagen cross-linking process using an ethanol/water co-solvent
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 2, February 2010, Pages 403–408
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us