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Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release

Paper ID Volume ID Publish Year Pages File Format Full-Text
2061 99 2010 8 PDF Available
Title
Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release
Abstract

Poly(2-hydroxyethyl methacrylate) hydrogels containing β-cyclodextrin (pHEMA/β-CD) have been investigated as a platform for sustained release of ophthalmic drugs. First of all, pHEMA/β-CD hydrogel membranes and contact lenses were prepared by photopolymerization of HEMA, mono-methacrylated β-CD (mono-MA-β-CD) and trimethylolpropane trimethacrylate using a cast molding process. The hydrogels were characterized by Fourier transform infrared spectroscopy, equilibrium swelling ratio (ESR) and tensile tester. The results showed that the incorporation of β-CD in the hydrogels increased the ESR and tensile strength. Then, puerarin was used as a model to evaluate drug loading and in vitro and in vivo release behavior of the pHEMA/β-CD hydrogels. It was revealed that puerarin loading and in vitro release rate were dependent on β-CD content in the pHEMA/β-CD hydrogels. In rabbit eyes the pHEMA/β-CD hydrogel contact lenses exhibited longer mean residence times (MRTF) of puerarin in tear fluid than that of pHEMA contact lenses and 1% puerarin eye drops. The puerarin concentration in the aqueous humor of rabbit reached a maximum of 0.81 μg ml−1 after wearing the pHEMA/β-CD contact lens, which had been presoaked in 0.802 mg ml−1 puerarin solution for 4.81 h. Also, the pHEMA/β-CD contact lenses had a higher drug bioavailability in aqueous humor than puerarin eye drops. The data demonstrate that pHEMA/β-CD hydrogel contact lenses can effectively deliver puerarin through the cornea.

Keywords
Hydrogel; Cyclodextrin; Contact lenses; Ophthalmic delivery; Puerarin
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Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 2, February 2010, Pages 486–493
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us