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Photoprotective effect of Undaria crenata against ultraviolet B-induced damage to keratinocytes

Paper ID Volume ID Publish Year Pages File Format Full-Text
20631 43183 2013 9 PDF Available
Title
Photoprotective effect of Undaria crenata against ultraviolet B-induced damage to keratinocytes
Abstract

Chronic exposure of the skin to ultraviolet B (UVB) radiation induces oxidative stress, which plays a crucial role in the induction of skin cancer. The brown alga Undaria crenata is a potential source of antioxidant and anti-apoptotic compounds due to its capacity to produce protective compounds against environmental factors, including UV radiation. The aim of this study was to investigate the photoprotective properties of an U. crenata ethanol extract (UCE) against UVB-induced cell damage in human HaCaT keratinocytes. UCE exhibited absorbing effect of UVB (280–320 nm) and scavenging activity against the 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species induced by hydrogen peroxide and UVB rays. Furthermore, electron spin resonance spectrometry revealed the significant scavenging effect of UCE against superoxide anion and hydroxyl radical. UCE reduced UVB-induced apoptosis, as shown by a decrease in apoptotic bodies and nuclear and DNA fragmentation, resulting in the recovery of cell viability. UCE also decreased the degree of UVB-induced oxidative stress to lipids, proteins, and DNA as shown by a decrease in 8-isoprostane level, protein carbonylation and DNA tails. These results suggest that UCE protects human keratinocytes against UVB-induced oxidative stress.

Keywords
Human keratinocytes; Oxidative stress; Reactive oxygen species; Ultraviolet B; Undaria crenata
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Photoprotective effect of Undaria crenata against ultraviolet B-induced damage to keratinocytes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 116, Issue 2, August 2013, Pages 256–264
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us