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Galactosylation of human erythropoietin produced by chimeric chickens expressing galactosyltransferase

Paper ID Volume ID Publish Year Pages File Format Full-Text
20636 43184 2014 4 PDF Available
Title
Galactosylation of human erythropoietin produced by chimeric chickens expressing galactosyltransferase
Abstract

Human erythropoietin produced in the egg white of chimeric chicken contains N-glycan with lower amounts of terminal galactose and sialic acid; therefore, the chicken galactosyltransferase gene was introduced together with the human erythropoietin gene by a retroviral vector. We found that erythropoietin accumulated in the egg white was partially galactosylated.

Keywords
Transgenic chicken; Erythropoietin; Galactose; Galactosyltransferase; N-Glycan
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Galactosylation of human erythropoietin produced by chimeric chickens expressing galactosyltransferase
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 117, Issue 6, June 2014, Pages 676–679
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us