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Host–guest inclusion system of norathyriol with β-cyclodextrin and its derivatives: Preparation, characterization, and anticancer activity

Paper ID Volume ID Publish Year Pages File Format Full-Text
20653 43184 2014 5 PDF Available
Title
Host–guest inclusion system of norathyriol with β-cyclodextrin and its derivatives: Preparation, characterization, and anticancer activity
Abstract

The characterization, binding ability and inclusion complexation behavior of the inclusion complexes of norathyriol with β-cyclodextrin (β-CD) and its derivatives such as hydroxypropyl-β-cyclodextrin (HPβCD), sulfobutyl ether β-cyclodextrin (SBEβCD) and mono (6-ethylene-diamino-6-deoxy)-β-cyclodextrin (ENβCD) were investigated in both solution and solid state by means of femtosecond spectroscopy, 1H and 2D nuclear magnetic resonance, powder X-ray diffraction. The results showed that the aqueous solubility of the complexes was much higher than that of norathyriol. The cytotoxicity of complexes on human colon cancer cell lines HT-29, SW480, Lovo and HCT116 indicated that the antitumor activities of the complexes were better than that of norathyriol. This high antitumor activity, along with the satisfactory aqueous solubility of the complexes, will be potentially useful for their application on cancer chemotherapies.

Keywords
Norathyriol; β-Cyclodextrin; Inclusion complex; Binding ability; Characterization; Anticancer activity
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Host–guest inclusion system of norathyriol with β-cyclodextrin and its derivatives: Preparation, characterization, and anticancer activity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 117, Issue 6, June 2014, Pages 775–779
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us