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Formation of one-way-structured cultured neuronal networks in microfluidic devices combining with micropatterning techniques

Paper ID Volume ID Publish Year Pages File Format Full-Text
20690 43186 2012 4 PDF Available
Title
Formation of one-way-structured cultured neuronal networks in microfluidic devices combining with micropatterning techniques
Abstract

We present a simple method to regulate the direction of axon development in cultured neurons using microfabrication and microfluidics techniques. We fabricate a PDMS-based device and place it onto a chemically micropatterned glass substrate. We confirm that cultured neurons extend neurites along the medium flow direction and the micropatterned regions.

Keywords
Cultured neuronal networks; Microfluidics; Micropatterning; Poly(dimethylsiloxane) (PDMS); Neurite guidance
First Page Preview
Formation of one-way-structured cultured neuronal networks in microfluidic devices combining with micropatterning techniques
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 114, Issue 1, July 2012, Pages 92–95
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering