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Characterization of antibacterial activity of bikaverin from Fusarium sp. HKF15

Paper ID Volume ID Publish Year Pages File Format Full-Text
20743 43189 2014 6 PDF Available
Title
Characterization of antibacterial activity of bikaverin from Fusarium sp. HKF15
Abstract

Redeemed interest in discovery and characterization of naturally occurring antimicrobials arises from the fact that these compounds possess diverse biological activities useful in the development of new therapeutics. In this study, 35 fungi from extreme environments of effluent treatment plants were screened for antimicrobial activity. An isolate HKF15 produced antimicrobial compound that showed activities against pathogenic and multidrug resistant bacteria; and was identified as Fusarium sp. The active principle was separated through activity-guided HPLC fractionation of 1:1 ethyl acetate crude extract that was identified as bikaverin using HRMS and 1H NMR. Bikaverin is known for antitumor and antifungal activity and in this study; antibacterial activity of bikaverin was assessed, emphasizing the importance of repurposing of antibiotics.

Keywords
Fusarium; Bikaverin; 18S rRNA gene; Antimicrobial activity; Effluent treatment plant
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Characterization of antibacterial activity of bikaverin from Fusarium sp. HKF15
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 117, Issue 4, April 2014, Pages 443–448
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us