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Effects of 14C-labelled precursor feeding on production of beauvericin, enniatins H, I, and MK1688 by Fusarium oxysporum KFCC11363P

Paper ID Volume ID Publish Year Pages File Format Full-Text
20788 43191 2012 5 PDF Available
Title
Effects of 14C-labelled precursor feeding on production of beauvericin, enniatins H, I, and MK1688 by Fusarium oxysporum KFCC11363P
Abstract

The effects of 14C-labelled precursor feeding on the production of cyclic hexadepsipeptides were investigated by the mycelium of F. oxysporum KFCC11363P producing beauvericin along with enniatins H, I, and MK1688. Most 14C-phenylalanine and 14C-valine were incorporated easily into the biosynthetic pathway of 14C-labelled beauvericin in vivo by the mycelium. However, only a small amount of 14C-labelled enniatins could be detected by feeding of 14C-valine. When l-valine was fed as a precursor to the mycelium at large scale, the level of beauvericin increased to maximum followed by enniatins H and I. Feeding of l-valine did not affect the production of enniatin MK1688. These results suggest that l-valine feeding led to the production of d-hydroxyisovaleic acid in the mycelium and specifically enhanced the production of cyclic hexadepsipeptides containing d-hydroxyisovaleic acid, such as beauvericin and enniatins H and I.

Keywords
Fusarium oxysporum; Beauvericin; Enniatins; Biosynthesis; Precursor
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Effects of 14C-labelled precursor feeding on production of beauvericin, enniatins H, I, and MK1688 by Fusarium oxysporum KFCC11363P
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 113, Issue 1, January 2012, Pages 58–62
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us