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Copper-mediated growth of amyloid β fibrils in the presence of oxidized and negatively charged liposomes

Paper ID Volume ID Publish Year Pages File Format Full-Text
20942 43198 2011 5 PDF Available
Title
Copper-mediated growth of amyloid β fibrils in the presence of oxidized and negatively charged liposomes
Abstract

ABSTRACTAmyloid β protein (Aβ) from Alzheimer's disease formed fibrillar aggregates and their morphology depended on oxidized and negatively charged liposomes. The morphology of fibrillar aggregates was affected by Cu2+, together with their growth kinetics. This is because Cu2+ inhibited the nucleation step in the formation of amyloid Aβ fibrillar aggregates by forming Aβ/Cu complex inactive to the growth of fibrillar aggregates. In addition, this is probably because Cu2+ affected the fibrillar aggregate formed on the surface of liposomes. These findings would give a better understanding of the formation mechanism of amyloid fibrils on biomembranes.

Keywords
Amyloid β protein; Liposome; Copper ion; Morphology
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Copper-mediated growth of amyloid β fibrils in the presence of oxidized and negatively charged liposomes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 112, Issue 6, December 2011, Pages 611–615
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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