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Fibrous poly(chitosan-g-dl-lactic acid) scaffolds prepared via electro-wet-spinning

Paper ID Volume ID Publish Year Pages File Format Full-Text
2100 100 2008 11 PDF Available
Title
Fibrous poly(chitosan-g-dl-lactic acid) scaffolds prepared via electro-wet-spinning
Abstract

dl-Lactic acid was grafted onto chitosan to produce poly(chitosan-g-dl-lactic acid)(PCLA) copolymers. These PCLAs were then spun into submicron and/or nanofibers to fabricate scaffolds using an electro-wet-spinning technique. The diameter of fibers in different scaffolds could vary from about 100 nm to around 3 μm. The scaffolds exhibited various pore sizes ranging from about 1 μm to less than 30 μm and different porosities up to 80%. Two main processing parameters, that is, the concentration of PCLA solutions and the composition proportions of coagulation solutions, were optimized for obtaining desired scaffolds with well-controlled structures. The tensile properties of the scaffolds in both dry and hydrated states were examined. Significantly improved tensile strength and modulus for these fibrous scaffolds in their hydrated state were observed. The data collected from in vitro rabbit-fibroblast/scaffold culture showed that there were no substantial differences in the viability, density and distribution of cultured fibroblasts between PCLA scaffolds and pure chitosan scaffolds.

Keywords
Chitosan; dl-Lactic acid; Grafting copolymer; Electro-wet-spinning; Fibrous scaffold
First Page Preview
Fibrous poly(chitosan-g-dl-lactic acid) scaffolds prepared via electro-wet-spinning
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 4, July 2008, Pages 876–886
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering