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Hierarchical pore structure of calcium phosphate scaffolds by a combination of gel-casting and multiple tape-casting methods

Paper ID Volume ID Publish Year Pages File Format Full-Text
2103 100 2008 10 PDF Available
Title
Hierarchical pore structure of calcium phosphate scaffolds by a combination of gel-casting and multiple tape-casting methods
Abstract

The objective of this work was to design hierarchical pore structure scaffolds with potential applications in bone tissue regeneration. For that purpose, a bioceramic material such as biphasic calcium phosphate, which consists of a mixture of hydroxyapatite and β-tricalcium phosphate, was selected. Multilayer pieces (MLP) with hierarchical pore structure were developed employing a new technique that combines gel casting and adding porogens, using multiple tape-casting methods. Pieces with functionally graded porosity were fabricated using porogens with different sizes. The porogens used were Porlat K85 and Porlat K86 with diameters <150 μm and 150–300 μm, respectively. Two types of sintered tapes, with different porosity, no cracking and enough interconnection size were selected. MLP with hierarchical pore structure were designed by the multiple tape-casting method. Interconnected pores whose sizes increase from interior tapes (1.6–3.6 μm) towards exterior tapes (20–51.5 μm) and interpenetration between tapes were achieved. Delamination or cracking were not observed after heat treatment. The flexural strength of pieces was investigated by the three-point bending test. This new combination of methods offers the possibility of manufacturing scaffolds with interconnected pore sizes ranging from 1.6 to 51.5 μm.

Keywords
Biphasic calcium phosphate; Multiple tape-casting; Gel casting; Hierarchical pore structure; Porosity
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Hierarchical pore structure of calcium phosphate scaffolds by a combination of gel-casting and multiple tape-casting methods
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 4, July 2008, Pages 913–922
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us