Optical resolution of n-butyl d- and l-lactates using immobilized lipase catalyst
n-Butyl d- and l-lactates (BuDLa and BuLLa) were incubated with immobilized lipase. 1H-NMR showed that BuDLa reacted to oligomers, while BuLLa did not react. A mixture containing 90.4% of BuLLa and 9.6% of BuDLa was incubated with the enzyme for 72 h, then distilled. The purity of BuLLa increased to 98.6%.
Journal: Journal of Bioscience and Bioengineering - Volume 111, Issue 1, January 2011, Pages 19–21