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Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(l-lactide) composites

Paper ID Volume ID Publish Year Pages File Format Full-Text
2113 100 2008 11 PDF Available
Title
Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(l-lactide) composites
Abstract

Novel bioactive glass (BG) nanoparticles/poly(l-lactide) (PLLA) composites were prepared as promising bone-repairing materials. The BG nanoparticles (Si:P:Ca = 29:13:58 weight ratio) of about 40 nm diameter were prepared via the sol–gel method. In order to improve the phase compatibility between the polymer and the inorganic phase, PLLA (Mn = 9700 Da) was linked to the surface of the BG particles by diisocyanate. The grafting ratio of PLLA was in the vicinity of 20 wt.%. The grafting modification could improve the tensile strength, tensile modulus and impact energy of the composites by increasing the phase compatibility. When the filler loading reached around 4 wt.%, the tensile strength of the composite increased from 56.7 to 69.2 MPa for the pure PLLA, and the impact strength energy increased from 15.8 to 18.0 kJ m−2. The morphology of the tensile fracture surface of the composite showed surface-grafted bioactive glass particles (g-BG) to be dispersed homogeneously in the PLLA matrix. An in vitro bioactivity test showed that, compared to pure PLLA scaffold, the BG/PLLA nanocomposite demonstrated a greater capability to induce the formation of an apatite layer on the scaffold surface. The results of marrow stromal cell culture revealed that the composites containing either BG or g-BG particles have much better biocompatibility compared to pure PLLA material.

Keywords
Polylactide; Bioactive glass; Nanoparticles; Composites; Mechanical properties
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Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(l-lactide) composites
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 4, July 2008, Pages 1005–1015
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us