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Microbial β-glycosylation of entacapone by Cunninghamella echinulata ATCC 9245

Paper ID Volume ID Publish Year Pages File Format Full-Text
21143 43208 2012 3 PDF Available
Title
Microbial β-glycosylation of entacapone by Cunninghamella echinulata ATCC 9245
Abstract

The purpose of this paper is to describe the glycosylation of entacapone by cultures of Cunninghamella echinulata ATCC 9245. This method is then applied in toxicological and pharmacological studies. The cultures were grown in a fluid PDSM medium for 7 days at 28°C. After purification by silica gel flash column chromatography, the (E)-2-cyano-N,N-diethyl-3-(4-hydroxy-3-nitro-5-(3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)phenyl) acrylamide was identified by IR, mass spectroscopy and 1H and 13 C NMR. The correct position and β-configuration of the glucose was determined through HSQC, HMBC and NOE experiments.

Keywords
Microbial glycosylation; Entacapone; Cunninghamella echinulata ATCC 9245; Biotransformation; Glycosylate entacapone
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Microbial β-glycosylation of entacapone by Cunninghamella echinulata ATCC 9245
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 113, Issue 5, May 2012, Pages 611–613
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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