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Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
21233 43213 2010 4 PDF Available
Title
Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering
Abstract

Aspergillus oryzae penicillin biosynthetic genes were clustered. The penicillin production was positively regulated by VeA, a global gene regulator required for transcriptional expression of the penicillin biosynthetic genes. Overexpression of the biosynthetic genes by a strong promoter yielded a greater than 100-fold increase in penicillin production.

Keywords
Aspergillus oryzae; Secondary metabolism; Penicillin; VeA; Genetic engineering
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Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 110, Issue 1, July 2010, Pages 8–11
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us