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Mechanical verification of soft-tissue attachment on bioactive glasses and titanium implants

Paper ID Volume ID Publish Year Pages File Format Full-Text
2126 100 2008 5 PDF Available
Title
Mechanical verification of soft-tissue attachment on bioactive glasses and titanium implants
Abstract

Soft-tissue attachment is a desired feature of many clinical biomaterials. The aim of the current study was to design a suitable experimental method for tensile testing of implant incorporation with soft-tissues. Conical implants were made of three compositions of bioactive glass (SiO2–P2O5–B2O3–Na2O–K2O–CaO–MgO) or titanium fiber mesh (porosity 84.7%). The implants were surgically inserted into the dorsal subcutaneous soft-tissue or back muscles in the rat. Soft-tissue attachment was evaluated by pull-out testing using a custom-made jig 8 weeks after implantation. Titanium fiber mesh implants had developed a relatively high pull-out force in subcutaneous tissue (12.33 ± 5.29 N, mean ± SD) and also measurable attachment with muscle tissue (2.46 ± 1.33 N). The bioactive glass implants failed to show mechanically relevant soft-tissue bonding. The experimental set-up of mechanical testing seems to be feasible for verification studies of soft-tissue attachment. The inexpensive small animal model is beneficial for large-scale in vivo screening of new biomaterials.

Keywords
Soft-tissue attachment; Bioactive glass; Titanium implant; Mechanical testing; Rat
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Mechanical verification of soft-tissue attachment on bioactive glasses and titanium implants
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 4, July 2008, Pages 1118–1122
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us