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Sentinel lymph node mapping using near-infrared fluorescent methylene blue

Paper ID Volume ID Publish Year Pages File Format Full-Text
21341 43217 2009 5 PDF Available
Title
Sentinel lymph node mapping using near-infrared fluorescent methylene blue
Abstract

Methylene blue (MB) is a safe, low cost, and common blue dye remaining a popular choice for sentinel lymph node (SLN) mapping. However, the blue-dyed SLN in deep animal tissue could be seen only after a surgical management. Here the fluorescence properties of MB were investigated using a fluorescence spectrometer and a wavelength-resolved fluorescence spectral in vivo imaging system, and MB has been demonstrated for near-infrared (NIR) fluorescence mapping of SLN. When MB was injected intradermally into the second row breast of a rabbit, the lymphatic flow and axillary SLN could be observed directly through the NIR fluorescence emitted from the MB trapped in the deep tissue, which would eliminate the need for surgical management, and this fluorescence without any radioactivity was retained in the SLN for hours. The node also could be identified synchronously by the blue color and fluorescence of the MB after a surgical management. Using MB NIR fluorescence for SLN mapping may have great advantages over the traditional method.

Keywords
Methylene blue; Near-infrared fluorescence; Sentinel lymph node; In vivo imaging; Mapping
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 107, Issue 4, April 2009, Pages 455–459
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us