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Combination of cytomegalovirus enhancer with human cellular promoters for gene-induced chondrogenesis of human bone marrow mesenchymal stem cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
21565 43228 2010 4 PDF Available
Title
Combination of cytomegalovirus enhancer with human cellular promoters for gene-induced chondrogenesis of human bone marrow mesenchymal stem cells
Abstract

High-expression plasmid vectors for human mesenchymal stem cells (MSCs) were constructed by combination of cytomegalovirus immediate-early enhancer with cellular promoters. MSCs transfected with the vector showed higher transgene production of a cytokine, which increased the differentiation level to chondrocytes.

Keywords
Cartilage regeneration; Gene therapy; Human mesenchymal stem cell; Nonviral-transfection; CMV enhancer; Human cellular promoter
First Page Preview
Combination of cytomegalovirus enhancer with human cellular promoters for gene-induced chondrogenesis of human bone marrow mesenchymal stem cells
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 110, Issue 5, November 2010, Pages 593–596
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering