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One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene

Paper ID Volume ID Publish Year Pages File Format Full-Text
21859 43240 2009 3 PDF Available
Title
One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene
Abstract

Pladienolide D is a 16-hydroxylated derivative of pladienolide B, produced by Streptomyces platensis. To facilitate the production of pladienolide D, the gene encoding a pladienolide B 16-hydroxylase from S. bungoensis was introduced into S. platensis. The recombinant produced pladienolide D at a production level comparable to that of pladienolide B.

Keywords
Pladienolide; Streptomycetes; Cytochrome P450 monooxygenase; One-pot; Fermentation
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One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 107, Issue 6, June 2009, Pages 596–598
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us