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Transport of human immunoglobulin G and Fc-fusion proteins to chicken egg yolk

Paper ID Volume ID Publish Year Pages File Format Full-Text
21878 43241 2006 6 PDF Available
Title
Transport of human immunoglobulin G and Fc-fusion proteins to chicken egg yolk
Abstract

We examined the transport of human immunoglobulin G (IgG) subclasses and fusion proteins with the Fc region of human IgG to the egg yolk, after the proteins were injected into a vein of hens. Human IgGs were efficiently transported and accumulated into the yolk, whereas the proteins were not detected in the egg white. Among human IgG subclasses, IgG2 was transported most efficiently. Fc-fusion proteins injected were also transported into the yolk. A fusion protein with the Fc region derived from human IgG2 was more efficiently transported into the yolk than the counterpart fusion with the Fc region from human IgG1. This study shows that the recovery of recombinant antibodies and Fc-fusion proteins from the yolk is an effective method in transgenic chicken bioreactors.

Keywords
chicken; yolk transport; immunoglobulin G (IgG) subclass; Fc-fusion protein; transgenic chicken bioreactor
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Transport of human immunoglobulin G and Fc-fusion proteins to chicken egg yolk
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 102, Issue 6, December 2006, Pages 518–523
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us