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Bioconversion of 1-adamantanol to 1,3-adamantanediol using Streptomyces sp. SA8 oxidation system

Paper ID Volume ID Publish Year Pages File Format Full-Text
21894 43242 2010 4 PDF Available
Title
Bioconversion of 1-adamantanol to 1,3-adamantanediol using Streptomyces sp. SA8 oxidation system
Abstract

To efficiently produce 1,3-adamantanediol (1,3-ad(OH)2) from 1-adamantanol (1-adOH), our stocks of culture strains and soil microorganisms were surveyed for hydroxylation activity towards 1-adOH. Among them, the soil actinomycete SA8 showing the highest hydroxylation activity was identified as Streptomyces sp. based on 16S ribosomal DNA sequence analysis. The reaction products were purified by silica gel column chromatography, and from NMR and MS analyses, they were identified as 1,3-ad(OH)2 and 1,4-ad(OH)2. Streptomyces sp. SA8 produced 5.9 g l− 1 1,3-ad(OH)2from 6.2 g l− 1 1-adOH in culture broth after 120 h at 25 °C. Using resting cells, 2.3 g l− 1 1,3-ad(OH)2 was produced after 96 h of incubation at a 69% conversion rate. In both cases, 1,4-ad(OH)2 was formed as a byproduct at a rate of about 15%. Strain SA8 also hydroxylated 2-adamantanol and 2-methyl-2-adamantanol.

Keywords
1-adamantanol; 1,3-adamantanediol; hydroxylation; Streptomyces sp. SA8; regio-selective
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Bioconversion of 1-adamantanol to 1,3-adamantanediol using Streptomyces sp. SA8 oxidation system
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 109, Issue 6, June 2010, Pages 550–553
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us