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Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis

Paper ID Volume ID Publish Year Pages File Format Full-Text
21918 43243 2008 7 PDF Available
Title
Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis
Abstract

Control of the G1/S phase transition of the cell cycle contributes to the maintenance of homeostasis. It is well known that the disruption of the cell cycle is related to cell transformation and carcinogenesis. The G1/S phase transition involves a network of components that includes cyclins, cyclin-dependent kinases, and other proteins. Numerical simulation techniques and system analysis are expected to become powerful tools for investigating complex biological networks. To reach this goal, we designed a mathematical model of the G1/S phase transition. Using our model, we conducted a numerical simulation and comprehensive system analyses of this phase of the cell cycle. In this way, we were able to predict the key factors involved in the control of the G1/S transition.

Keywords
mathematical modeling; system biology; G1/S phase; system analysis; mammalian cell cycle
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 106, Issue 4, October 2008, Pages 368–374
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us