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Inducing Chondrogenic Differentiation in Injectable Hydrogels Embedded with Rabbit Chondrocytes and Growth Factor for Neocartilage Formation

Paper ID Volume ID Publish Year Pages File Format Full-Text
21935 43244 2008 5 PDF Available
Title
Inducing Chondrogenic Differentiation in Injectable Hydrogels Embedded with Rabbit Chondrocytes and Growth Factor for Neocartilage Formation
Abstract

A thermoreversible hydrogel of poly(NiPAAm-co-AAc) was used as an injectable cell and growth factor delivery carrier for cartilage tissue engineering. Rabbit chondrocytes were embedded in composite hydrogels coencapsulated with transforming growth factor β3 (TGFβ3). Hydrogel constructs consisting of embedded cells encapsulated by the thermoreversible hydrogel served as controls to assess the effects of TGFβ3 on chondrogenic differentiation. The hydrogel constructs were injected subcutaneously into nude mice and then monitored for up to 8 weeks after injection. After 8 weeks of implantation, the engineered cartilage acquired normal histological and biochemical properties. These results highlight the potential of growth factor in a hydrogel embedded with chondrocytes as a candidate material for neocartilage formation.

Keywords
cartilage; chondrocytes; thermosensitive hydrogel; transforming growth factor β3 (TGF β3)
First Page Preview
Inducing Chondrogenic Differentiation in Injectable Hydrogels Embedded with Rabbit Chondrocytes and Growth Factor for Neocartilage Formation
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 105, Issue 2, February 2008, Pages 122–126
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering