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Augmentation of Polysialic Acid by Valproic Acid in Early Postnatal Mouse Hippocampus and Primary Cultured Hippocampal Neurons

Paper ID Volume ID Publish Year Pages File Format Full-Text
21943 43244 2008 4 PDF Available
Title
Augmentation of Polysialic Acid by Valproic Acid in Early Postnatal Mouse Hippocampus and Primary Cultured Hippocampal Neurons
Abstract

We examined the effects of valproic acid (VPA) on hippocampal neurons. Prenatal VPA exposure significantly increased polysialic acid (PSA) expression in the early postnatal mouse hippocampus. Moreover, VPA treatment significantly enhanced PSA expression in primary cultured hippocampal neurons and stimulated neurite growth. Our results suggest that VPA exposure in ovo affects hippocampal development.

Keywords
polysialic acid; valproate; neurite growth; hippocampus
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Augmentation of Polysialic Acid by Valproic Acid in Early Postnatal Mouse Hippocampus and Primary Cultured Hippocampal Neurons
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 105, Issue 2, February 2008, Pages 164–167
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us