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Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins

Paper ID Volume ID Publish Year Pages File Format Full-Text
22033 43249 2006 3 PDF Available
Title
Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins
Abstract

We investigated the aqueous solubility of paclitaxel using 11 kinds of cyclodextrins (CDs) and the bioactivity of the paclitaxel-CD inclusion complex. 2,6-Dimethyl β-cyclodextrin was the most effective and its solubility was 2.3 mM in a 0.1 M 2,6-dimethyl β-cyclodextrin aqueous solution. The inclusion complex of paclitaxel and 2,6-dimethyl β-cyclodextrin had a 1.23-fold polymerization activity as paclitaxel in a tubulin assay.

Keywords
paclitaxel; cyclodextrin; inclusion complex; water solubility
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Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 102, Issue 4, October 2006, Pages 369–371
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us