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Release of antihypertensive peptides in miso paste during its fermentation, by the addition of casein

Paper ID Volume ID Publish Year Pages File Format Full-Text
22056 43251 2009 5 PDF Available
Title
Release of antihypertensive peptides in miso paste during its fermentation, by the addition of casein
Abstract

Casein hydrolysate by Aspergillus oryzae protease has been developed to obtain two kinds of antihypertensive peptides, Val-Pro-Pro and Ile-Pro-Pro. In this study, casein miso paste was prepared by adding casein at various concentrations during miso paste fermentation in order to release angiotensin-I converting enzyme (ACE) inhibitory peptides. Increase of peptide concentration and ACE inhibitory activity in casein miso paste was observed and corresponded to the degradation of casein and soy bean proteins during fermentation for 7 days. ACE inhibitory activity of the casein miso paste was higher than that of the general (casein-free) miso paste after fermentation for 7 days. The levels of ACE inhibitory peptides, Val-Pro-Pro and Ile-Pro-Pro, were increased in the casein miso paste during the fermentation. Significant antihypertensive effects of casein miso paste compared to water and the general miso paste (P < 0.05 and P < 0.05) were confirmed in spontaneously hypertensive rats at a dosage of 1.8 g of the casein miso paste/kg of BW. Taken into account of minimum effective dosages of Val-Pro-Pro and Ile-Pro-Pro in previous clinical studies, these results suggest that casein miso paste might have the potential to control blood pressure in humans.

Keywords
Miso paste; Antihypertensive peptide; Angiotensin-I converting enzyme; Aspergillus oryzae; Spontaneously hypertensive rats
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Release of antihypertensive peptides in miso paste during its fermentation, by the addition of casein
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 108, Issue 2, August 2009, Pages 111–115
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us