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Synergic stimulation of laminin and epidermal growth factor facilitates the myoblast growth through promoting migration

Paper ID Volume ID Publish Year Pages File Format Full-Text
22067 43251 2009 4 PDF Available
Title
Synergic stimulation of laminin and epidermal growth factor facilitates the myoblast growth through promoting migration
Abstract

The dynamic behaviors of human skeletal muscle myoblasts were investigated in the culture on a laminin-coated surface in the presence of 100 ng/ml epidermal growth factor (EGF) in medium. The coexistence of laminin and EGF caused the enhancement of myoblast migration, giving an average migration rate of 62.0 μm/h, which was 2.7 times that on a plain surface. This encouraged migration could be a driving force to separate the dividing cells from each other, accompanied by shortened disjunction time of daughter cells to complete cytokinesis. In addition, the synergic effect of laminin and EGF led to the promotion of myoblast growth with keeping a relatively high fraction of proliferative cells during the culture for 150 h, which is considered to arise from the reduced frequency of cell–cell contacts during cytokinesis and thereby suppressing the process towards myotube formation after cell division.

Keywords
Myoblast cells; Laminin; Epidermal growth factor; Migration; Cytokinesis
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Synergic stimulation of laminin and epidermal growth factor facilitates the myoblast growth through promoting migration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 108, Issue 2, August 2009, Pages 174–177
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us