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Bicompartmental device for dynamic cell coculture: Design, realisation and preliminary results

Paper ID Volume ID Publish Year Pages File Format Full-Text
22093 43253 2008 9 PDF Available
Title
Bicompartmental device for dynamic cell coculture: Design, realisation and preliminary results
Abstract

Low-shear perfusion and compartmental systems are very important conceptual designs for the realization of high-density cell cultures and cocultures, thus allowing very realistic models and therefore reliable results. In this work, we combines low-shear perfusion and multi-compartments in one device. We also describe the design, fabrication and validation of a bicompartmental, low-perfusion culture chamber specifically designed for applications in various fields, such as tissue engineering, pharmacology, molecular biology, pharmacokinetics, nanomedicine, and drug delivery testing. The device properties in terms of flow features and metabolite exchange capabilities are fully characterized. In vitro tests performed on cell lines confirm the effectiveness of the device as an experimental tool for measurements in dynamic and multiple-cell cultures and cocultures.

Keywords
cell culture device; multi-compartmental multiple cell cultures; cellular coculture; bioreactor; dynamic culture; tissue engineering
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Bicompartmental device for dynamic cell coculture: Design, realisation and preliminary results
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 105, Issue 5, May 2008, Pages 536–544
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us